Ceramisys
Bone Graft Substitute  
 
Ceramisys ReproBone Implantable Synthetic Bone Graft Substitutes

ReproBone™ bone graft
substitutes are manufactured in granular and paste forms.
The chemical composition of their matrices is very similar to that found in human cancellous bone and acts as an ideal scaffold for bone support and regeneration.

 

Copyright Ceramisys 2011

 

BONE GRAFT SUBSTITUTE
CLINICAL PERFORMANCE


ReproBone™
Blocks / Granules / Discs / Wedges
ReproBone™ has proven biocompatibility and osteoconductivity. Studies show that ReproBone™ implanted both in cancellous bone and cortical bone provides excellent osseointegration with rapid bone penetration through to the core of the implant.
1. OSTEOCONDUCTION
Bone radiating through pores to the centre of the implant.

2. INTEGRATION
At 12 weeks complete integration with new bone, implant is now embedded within new bone forming bicontinuous matrix.

3. CONSOLIDATION & MATURATION
Osteoclastic resorption and phagocytosis, releases calcium and phosphate ions locally, which in turn encourages osteoblastic activity and the deposition of new bone. Bone remodelling transforms initially woven bone into lamellar bone.

4. RESORPTION
At 12 weeks osteoclastic resorption can be clearly observed, the implant has a distinctly blurred outline with highly microporous surface. Bone remodelling continues until the implant is completely resorbed.

PROPERTIES

 
ReproBone™
BLOCKS/GRANULES/DISCS/WEDGES
COMPOSITION 60% HA, 40% ß-TCP
POROSITY 83%
MACROPOROSITY 200 - 800um
FULLY INTERCONNECTED Yes
MICROPOROSITY 1.0 - 10um
STERILITY Gamma irradiated
   
BONE GRAFT SUBSTITUTE
ReproBone™
'Cancellous like' structure
ReproBone Cancellous like structure
1.
Osteoconduction
2&3.
Integration, Consolidation and Maturation
4.
Osteoclastic Resorption