Ceramisys
Bone Graft Substitute  
 
Ceramisys ReproBone Implantable Synthetic Bone Graft Substitutes

ReproBone™ bone graft
substitutes are manufactured in granular and paste forms.
The chemical composition of their matrices is very similar to that found in human cancellous bone and acts as an ideal scaffold for bone support and regeneration.

 

Copyright Ceramisys 2011

 

BONE GRAFT SUBSTITUTE
PASTE PERFORMANCE


ReproBone novo
Nanocrystalline Synthetic Bone Graft Paste

ReproBone novo™ has proven biocompatibility and bone regenerative properties. Studies show that ReproBone novo™ implanted in cancellous bone provides excellent osseointegration with rapid vascularisation and bone penetration through to the core of the implant.
1. APPLICATION & PRIMARY STAGES
The non-hardening mouldable paste does not form a barrier to adjacent healthy bone cells, the sticky paste ensures good contact and cells readily migrate inwards. Blood passively infiltrates, bringing with it the growth factors needed for bone regeneration, and early vascularisation takes place.

2. BONE FORMATION
ReproBone novo™ stimulates bone healing by accelerating the rate at which bone-forming cells proliferate, resulting in a rapid building of new bone.

The bone defect is regenerated with new woven bone after several weeks. In parallel the graft has been almost completely resorbed by macrophages and osteoclasts. Remodelling and maturation of the bone continues as normal.

PROPERTIES

 
ReproBone novo™ PASTE
HIGH SURFACE AREA Approx 100M2/g
HYDROXYAPATITE CONTENT Nominal 38%
HA NANOTECHNOLOGY 30-50nm particles
PRODUCT VOLUME Various 0.5cc to 15cc
STERILITY Gamma irradiated
   
BONE GRAFT SUBSTITUTE PASTE

 

 

1.
ReproBone novo paste application and primary stages
2.
Bone formation